Lymphoid Tissue by T Cells in Murine Gut-Associated Induces Activation and Cytokine Production Superantigen Staphylococcal Enterotoxin B Oral Administration of the Bacterial
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Staphylococcal enterotoxin B primes cytokine secretion and lytic activity in response to native bacterial antigens.
Superantigens stimulate T-lymphocyte proliferation and cytokine production, but the effects of superantigen exposure on cell function within a complex, highly regulated immune response remain to be determined. In this study, we demonstrate that superantigen exposure significantly alters the murine host response to bacterial antigens in an in vitro coculture system. Two days after exposure to th...
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We have used staphylococcal enterotoxin B (SEB) to study the role of naive and memory T cells in the induction of peripheral tolerance. After administration of SEB to mice, the numbers of naive and memory T cells increase, as does the proportion of memory T cells, which are unresponsive to further stimulation with SEB in vitro. In addition, memory T cells generated in response to conventional a...
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